Coronado-Cáceres, Luis Jorge; Rabadán-Chávez, Griselda; Quevedo-Corona, Lucía; Hernández-Ledesma, Blanca; Milliar-García, Angel; Mojica, Luis; Lugo-Cervantes, Eugenia.
Journal of Functional Foods 62, 103519.
https://doi.org/10.1016/j.jff.2019.103519
Resumen
The objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity.
The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight of WAT, serum triglycerides, NEFAs, insulin, and leptin levels, and pro-inflammatory factors, with an increase in serum HDL levels, activation (AMPK, PPAR-γ, PPAR-α, SIRT1, Plin1, and PGC-1α) and repression (TNF-α, SREBP-1c, Leptin and ACC) of the mRNA of transcription factors and proteins related to WAT dysfunction. The CP prevented dysfunction in WAT who is related to obesity by down-regulation of factors related to lipogenesis and up-regulation of those related to energy expenditure, lowering the release of triglycerides and NEFAs into peripheral tissues, thus decreasing
pro-inflammatory processes.
